PF-3845
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $830 | Check With Us |
| 500mg | $1140 | Check With Us |
| 1g | $1710 | Check With Us |
: Cat #: V0908 CAS #: 1196109-52-0 Purity ≥ 98%
Description: PF-3845 (PF3845; PF 3845) is a novel, biaryl ether piperidine-based, selective and covalent/irreversible inhibitor of FAAH (fatty acid amide hydrolase) with anti-inflammatory, antidiarrheal and antinociceptive effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 456.46 |
|---|---|
| Molecular Formula | C24H23F3N4O2 |
| CAS No. | 1196109-52-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 91 mg/mL (199.4 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 91 mg/mL (199.4 mM) | |
| Solubility In Vivo | 30% propylene glycol, 5% Tween 80, 65% D5W: 15mg/mL |
| SMILES Code | O=C(N1CCC(CC2=CC=CC(OC3=NC=C(C(F)(F)F)C=C3)=C2)CC1)NC4=CC=CN=C4 |
| Synonyms | PF-3845; PF 3845; PF3845; |
| Protocol | In Vitro | PF-3845 (0.5 nM-10 μM; 40 min) inhibits human FAAH-1 (IC50=18 nM) in a concentration-dependent manner, and shows negligible activity against FAAH-2 (IC50>10 μM) in COS-7 cells. |
|---|---|---|
| In Vivo | PF-3845 (10 mg/kg; a single i.p.) causes a dramatic and sustained elevation in Anandamide (AEA) in mice. PF-3845 (10 mg/kg; a single i.p.) selectively inhibits FAAH in mice for up to 24 hours. PF-3845 (1-30 mg/kg; p.o.) produces cannabinoid receptor-dependent reductions in inflammatory pain in rat. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1908 mL | 10.9539 mL | 21.9077 mL | 43.8154 mL |
| 5mM | 0.4382 mL | 2.1908 mL | 4.3815 mL | 8.7631 mL |
| 10mM | 0.2191 mL | 1.0954 mL | 2.1908 mL | 4.3815 mL |
| 20mM | 0.1095 mL | 0.5477 mL | 1.0954 mL | 2.1908 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.