PF-06815345 HCl

This product is for research use only, not for human use. We do not sell to patients.

PF-06815345 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$180To Be Confirmed
5mg$520To Be Confirmed
10mg$880To Be Confirmed
email: [email protected]        [email protected]

Cat #: V41854 CAS #: 2334434-49-8 Purity ≥ 99%

Description: PF-06815345 HCl (PF06815345) is a liver targeted prodrug of PCSK9 inhibitor which is orally bioavailable and has to be converted by liver carboxyesterase (CES1) to its zwitterionic active drug that selectively inhibits PCSK9 protein synthesis. PCSK9 is a novel therapeutic target for preventing and treating atherosclerosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in regulating lipoprotein metabolism by binding to low-density lipoprotein receptors (LDLRs), leading to their degradation. LDL cholesterol (LDL-C) lowering drugs that operate through the inhibition of PCSK9 are being pursued for the management of hypercholesterolemia and reducing its associated atherosclerotic cardiovascular disease (CVD) risk. Two PCSK9-blocking monoclonal antibodies (mAbs), alirocumab and evolocumab, were approved in 2015.

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Molecular Weight (MW)634.489406108856
Molecular FormulaC27H30CL2FN9O4
CAS No.2334434-49-8
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.

SynonymsPF06815345 HClPF 06815345 HClPF-06815345 HClPF-06815345 hydrochloride
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.5761 mL7.8804 mL15.7607 mL31.5214 mL
5mM0.3152 mL1.5761 mL3.1521 mL6.3043 mL
10mM0.1576 mL0.7880 mL1.5761 mL3.1521 mL
20mM0.0788 mL0.3940 mL0.7880 mL1.5761 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.