PF-06447475
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $390 | Check With Us |
| 500mg | $580 | Check With Us |
| 1g | $870 | Check With Us |
: Cat #: V2916 CAS #: 1527473-33-1 Purity ≥ 98%
Description: PF-06447475 (PF06447475) is a novel, highly potent, selective and brain penetrable inhibitor of Leucine rich repeat kinase 2 (LRRK2) with anti-PD activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 305.33 |
|---|---|
| Molecular Formula | C17H15N5O |
| CAS No. | 1527473-33-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 33 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: N/A | |
| SMILES Code | N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1 |
| Synonyms | PF6447475; PF-06447475; PF-6447475; PF06447475; PF 6447475; PF 06447475 |
| Protocol | In Vitro | PF-06447475 inhibits LRRK2 enzyme and LRRK2 in the whole cell assay with IC50s of 3 and 25 nM, respectively. |
|---|---|---|
| In Vivo | PF-06447475 is well tolerated in rats. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2751 mL | 16.3757 mL | 32.7514 mL | 65.5029 mL |
| 5mM | 0.6550 mL | 3.2751 mL | 6.5503 mL | 13.1006 mL |
| 10mM | 0.3275 mL | 1.6376 mL | 3.2751 mL | 6.5503 mL |
| 20mM | 0.1638 mL | 0.8188 mL | 1.6376 mL | 3.2751 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.