PF-04957325

This product is for research use only, not for human use. We do not sell to patients.

PF-04957325
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1950Check With Us
200mg$2925Check With Us
500mg$4935Check With Us

Cat #: V4469 CAS #: 1305115-80-3 Purity ≥ 98%

Description: PF-04957325 (PF04957325) is a novel, highly potent and selective PDE8 inhibitor with important biological activity.

References: Vang AG, et al. Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Front Pharmacol. 2016 Aug 23;7:259.

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Product Promise

Promise
Molecular Weight (MW)400.38
Molecular FormulaC₁₄H₁₅F₃N₈OS
CAS No.1305115-80-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeNC1=C(N=NN2C[C@H]3CN(CC4=NC=CS4)CCO3)C2=NC(C(F)(F)F)=N1
SynonymsPF-04957325; PF 04957325; PF04957325
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4976 mL12.4881 mL24.9763 mL49.9525 mL
5mM0.4995 mL2.4976 mL4.9953 mL9.9905 mL
10mM0.2498 mL1.2488 mL2.4976 mL4.9953 mL
20mM0.1249 mL0.6244 mL1.2488 mL2.4976 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.