PF-03654746 | CAS 935840-31-6

PF-03654746

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$3250	To Be Confirmed
100mg	$4875	To Be Confirmed
200mg	$7310	To Be Confirmed

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Cat #: V4310 CAS #: 935840-31-6 Purity ≥ 98%

Description: PF-03654746 is a novel, potent, specific and selective histamine H3 receptor antagonist with >1000-fold selectivity for the H 3 receptor over the other histamine receptor subtypes. It is undergoing clinical trials for the treatment of ADHD, Tourette syndrome as well as potential anti-allergy applications. A previous clinical trial employing a nasal ragweed bolus after administration of PF-03654746 (an H 3 receptor antagonist with similar structure to PF-03654764) + fexofenadine demonstrated significantly reduced congestion, compared to placebo. However, PF-03654764 has never been tested in a randomized controlled trial of allergic rhinitis, or in the Environmental Exposure Unit (EEU), which better approximates real life by delivering the allergen in the ambient air.

References: Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	322.4
Molecular Formula	C18H24F2N2O
CAS No.	935840-31-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C([C@H]1C[C@](C2=CC=C(CN3CCCC3)C(F)=C2)(F)C1)NCC
Synonyms	PF-03654746; PF 03654746; PF03654746.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1017 mL	15.5087 mL	31.0174 mL	62.0347 mL
5mM	0.6203 mL	3.1017 mL	6.2035 mL	12.4069 mL
10mM	0.3102 mL	1.5509 mL	3.1017 mL	6.2035 mL
20mM	0.1551 mL	0.7754 mL	1.5509 mL	3.1017 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.