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PF-00835231 (PF-835231)

This product is for research use only, not for human use. We do not sell to patients.

PF-00835231 (PF-835231)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1200Check With Us
200mg$1800Check With Us
500mg$3035Check With Us

Cat #: V41524 CAS #: 870153-29-0 Purity ≥ 99%

Description: PF-00835231 (PF-835231) is a potent 3CLpro [main protease (Mpro)] inhibitor developed by Pfizer for COVID-19 treatment.

References: Robert L Hoffman, et al. Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. J Med Chem. 2020 Nov 12;63(21):12725-12747.

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Product Promise

Promise
Molecular Weight (MW)472.53
Molecular FormulaC24H32N4O6
CAS No.870153-29-0
SMILES CodeOCC([C@H](C[C@@H]1CCNC1=O)NC([C@H](CC(C)C)NC(C2=CC3=C(OC)C=CC=C3N2)=O)=O)=O
SynonymsPF 835231; PF-835231; PF835231; PF 00835231; PF-00835231; PF00835231
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1163 mL10.5813 mL21.1627 mL42.3254 mL
5mM0.4233 mL2.1163 mL4.2325 mL8.4651 mL
10mM0.2116 mL1.0581 mL2.1163 mL4.2325 mL
20mM0.1058 mL0.5291 mL1.0581 mL2.1163 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.