PD-123319 TFA salt
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1240 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V2884 CAS #: 136676-91-0 Purity ≥ 98%
Description: PD 123319 ditrifluoroacetate is a novel, potent, and selective nonpeptide AT2 (angiotensin II) receptor antagonist with IC50 of 34 nM.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 736.67 |
|---|---|
| Molecular Formula | C35H34F6N4O7 |
| CAS No. | 136676-91-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >30 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: N/A | |
| SMILES Code | O=C([C@H]1N(CC2=C(C1)N(C=N2)CC3=CC=C(C(C)=C3)N(C)C)C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O. FC(C(O)=O)(F)F.FC(C(O)=O)(F)F |
| Synonyms | PD 123319 ditrifluoroacetate; PD-123319 TFA; PD-123319 DiTFA; PD 123319; PD123319 ditrifluoroacetate |
| Protocol | In Vitro | PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3575 mL | 6.7873 mL | 13.5746 mL | 27.1492 mL |
| 5mM | 0.2715 mL | 1.3575 mL | 2.7149 mL | 5.4298 mL |
| 10mM | 0.1357 mL | 0.6787 mL | 1.3575 mL | 2.7149 mL |
| 20mM | 0.0679 mL | 0.3394 mL | 0.6787 mL | 1.3575 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.