PARP-IN-1 (3-aminobenzamide; 3-ABA; 3-AB)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $320 | Check With Us |
| 10g | $500 | Check With Us |
| 20g | $750 | Check With Us |
: Cat #: V0306 CAS #: 3544-24-9 Purity ≥ 98%
Description: PARP-IN-1 (3-Aminobenzamide; 3-ABA; 3-AB) is a novel and potent inhibitor of PARP [ Poly(ADP-ribose)polymerase] with potential anticancer activity.
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| Molecular Weight (MW) | 136.15 |
|---|---|
| Molecular Formula | C₇H₈N₂O |
| CAS No. | 3544-24-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: N/Ar |
| H2O: ≥ 11.11 mg/mLr | |
| Ethanol: N/A | |
| Synonyms | 3-Aminobenzamide; PARP-IN-1; 3-ABA; 3-AB |
| Protocol | In Vitro | 3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 7.3448 mL | 36.7242 mL | 73.4484 mL | 146.8968 mL |
| 5mM | 1.4690 mL | 7.3448 mL | 14.6897 mL | 29.3794 mL |
| 10mM | 0.7345 mL | 3.6724 mL | 7.3448 mL | 14.6897 mL |
| 20mM | 0.3672 mL | 1.8362 mL | 3.6724 mL | 7.3448 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.