PARP-1-IN-3

This product is for research use only, not for human use. We do not sell to patients.

PARP-1-IN-3
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$250To Be Confirmed
10mg$410To Be Confirmed
email: [email protected]        [email protected]

Cat #: V41045 CAS #: 2976342-33-1 Purity ≥ 99%

Description: PARP-1-IN-3 is a benzamide analogue and a potent PARP-1 inhibitor (antagonist) with IC50s of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 causes apoptosis and arrests the cell cycle in the G2/M phase. PARP-1-IN-3 could be used in cancer research.

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Molecular Weight (MW)425.275284528732
Molecular FormulaC21H17BRN2O3
CAS No.2976342-33-1
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3514 mL11.7571 mL23.5142 mL47.0284 mL
5mM0.4703 mL2.3514 mL4.7028 mL9.4057 mL
10mM0.2351 mL1.1757 mL2.3514 mL4.7028 mL
20mM0.1176 mL0.5879 mL1.1757 mL2.3514 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.