Pantoprazole (BY1023)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$400	Check With Us
5g	$700	Check With Us
10g	$1050	Check With Us

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Cat #: V1637 CAS #: 102625-70-7 Purity ≥ 98%

Description: Pantoprazole (BY1023; SKF96022; BY-1023; SKF-96022; Protonix), an approved anti-ulcer drug, is a proton pump inhibitor (PPI) used for short-term treatment of erosion and ulceration of the esophagus caused by GERD (gastroesophageal reflux disease).

References: Krupa J Patel, et al. Use of the proton pump inhibitor pantoprazole to modify the distribution and activity of doxorubicin: a potential strategy to improve the therapy of solid tumors. Clin Cancer Res. 2013 Dec 15;19(24):6766-76.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	383.37
Molecular Formula	C16H15F2N3O4S
CAS No.	102625-70-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 76 mg/mL (198.2 mM)r
	Water:<1 mg/mLr
	Ethanol: 76 mg/mL (198.2 mM)
Synonyms	BY1023; SKF96022; Protonix; BY 1023; SKF 96022; BY-1023; SKF-96022

Protocol	In Vitro	Pantoprazole (BY1023; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells
	In Vivo	Pantoprazole (BY1023; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin.
	Animal model	Mice bearing MCF-7 or A431 xenografts
	Dosages	200 mg/kg
	Administration	IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6084 mL	13.0422 mL	26.0845 mL	52.1689 mL
5mM	0.5217 mL	2.6084 mL	5.2169 mL	10.4338 mL
10mM	0.2608 mL	1.3042 mL	2.6084 mL	5.2169 mL
20mM	0.1304 mL	0.6521 mL	1.3042 mL	2.6084 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.