Pamufetinib (TAS-115)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1040 | To Be Confirmed |
| 250mg | $1800 | To Be Confirmed |
| 500mg | $2700 | To Be Confirmed |
: Cat #: V3856 CAS #: 1190836-34-0 Purity ≥ 98%
Description: Pamufetinib (TAS-115; TAS115) is a novel potent inhibitor of VEGFR and hepatocyte growth factor receptor (MET)-targeted kinase with anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 518.56 |
|---|---|
| Molecular Formula | C27H23FN4O4S |
| CAS No. | 1190836-34-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: < 1mg/mLr | |
| Ethanol: < 1mg/mL | |
| SMILES Code | O=C(NC(NC1=CC(F)=C(OC2=C(C=C(C(NC)=O)C(OC)=C3)C3=NC=C2)C=C1)=S)CC4=CC=CC=C4 |
| Synonyms | TAS115, Pamufetinib; TAS 115, TAS-115 |
| Protocol | In Vitro | Pamufetinib is ATP antagonism with inhibition constant (Ki) values against rVEGFR2 and rMET of 12 and 39 nM, respectively. Pamufetinib inhibits the kinase activity of both VEGFR2 and MET and their signal-dependent cell growth as strongly as other known VEGFR or MET inhibitors. Pamufetinib induces less damage in various normal cells than do other VEGFR inhibitors. |
|---|---|---|
| In Vivo | Pamufetinib (50 mg/kg/d) completely prevents tumor growth during the treatment period. Pamufetinib (200 mg/kg/d) induces a 48% regression from the initial tumor volume in MET-amplified human cancer transplanted models. The estimated 50% effective dose (ED50) of Pamufetinib in this model is 8 mg/kg/d. Pamufetinib significantly prolongs survival of these mice when administered at doses of 50 or 200 mg/kg/d. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9284 mL | 9.6421 mL | 19.2842 mL | 38.5683 mL |
| 5mM | 0.3857 mL | 1.9284 mL | 3.8568 mL | 7.7137 mL |
| 10mM | 0.1928 mL | 0.9642 mL | 1.9284 mL | 3.8568 mL |
| 20mM | 0.0964 mL | 0.4821 mL | 0.9642 mL | 1.9284 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.