P7C3 | CAS 301353-96-8

P7C3

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$828	Check With Us
500mg	$1329	Check With Us
1g	$1995	Check With Us

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Cat #: V0960 CAS #: 301353-96-8 Purity ≥ 98%

Description: P7C3 (P-7C3; P7 C-3; P 7C3) is a novel and potent proneurogenic and neuroprotective agent that acts by targeting the NAMPT (Nicotinamide phosphoribosyltransferase) enzyme.

References: Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	474.19
Molecular Formula	C21H18Br2N2O
CAS No.	301353-96-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 95 mg/mL (200.3 mM)r
	Water: <1 mg/mLr
	Ethanol: 20 mg/mL (42.2 mM)
SMILES Code	OC(CNC1=CC=CC=C1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
Synonyms	P7C3; P7 C3; P 7C3

Protocol	In Vitro	P7C3 inhibits LPS-induced production of pro-inflammatory factors in BV2 cells.
Protocol	In Vivo	P7C3 (20 mg/kg/d; i.p.; twice daily; for 21 days ) inhibits microglial activation and microglia-mediated dopaminergic (DA) neuronal loss in vivo.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1089 mL	10.5443 mL	21.0886 mL	42.1772 mL
5mM	0.4218 mL	2.1089 mL	4.2177 mL	8.4354 mL
10mM	0.2109 mL	1.0544 mL	2.1089 mL	4.2177 mL
20mM	0.1054 mL	0.5272 mL	1.0544 mL	2.1089 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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