Ozagrel HCl (OKY046 HCl; KCT0809; Cataclot)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$580	Check With Us
1g	$850	Check With Us
5g	$1275	Check With Us

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Cat #: V0817 CAS #: 78712-43-3 Purity ≥ 98%

Description: Ozagrel HCl (OKY-046 HCl; KCT 0809; Cataclot; Xanbo; OKY046 HCl), the hydrochloride salt of the antiplatelet drug Ozagrel, is a selective inhibitor of thromboxane A(2) (TXA(2)) synthetase (IC50 = 11 nM) with potential use for for the improving postoperative cerebrovascular contraction and accompanying cerebral ischaemia.

References: Max Seidy Saito, et al. Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1591-601.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	264.71
Molecular Formula	C13H12N2O2.HCl
CAS No.	78712-43-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 53 mg/mL (200.2 mM)r
	Water: 53 mg/mL (200.2 mM)r
	Ethanol: 6 mg/mL (22.7 mM)
Synonyms	OKY-046 HCl; KCT 0809; Cataclot; Xanbo; OKY046 HCl; Ozagrel hydrochloride, Ozagrel HCl; OKY 046 HCl; Ozagrel; KCT-0809; KCT0809; Ozagrel free acid

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.7777 mL	18.8886 mL	37.7772 mL	75.5544 mL
5mM	0.7555 mL	3.7777 mL	7.5554 mL	15.1109 mL
10mM	0.3778 mL	1.8889 mL	3.7777 mL	7.5554 mL
20mM	0.1889 mL	0.9444 mL	1.8889 mL	3.7777 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.