OSU-T315 (ILK-IN-1)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1500	Check With Us
500mg	$2500	Check With Us
1g	$3750	Check With Us

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Cat #: V31818 CAS #: 2070015-22-2 Purity ≥ 99%

Description: OSU-T315 (ILK-IN-1) is a novel, potent and specific small molecule inhibitor of Integrin-linked kinase (ILK) with an IC50 of 0.6 μM, suppressing cancer cell proliferation in vitro and in vivo and inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain).

References: Su-Lin Lee,et al Identification and Characterization of a Novel Integrin-Linked Kinase Inhibitor.J Med Chem. 2011 Sep 22; 54(18): 6364–6374

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Stock Solution Preparation
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Molecular Weight (MW)	533.59
Molecular Formula	C₃₀H₃₀F₃N₅O
CAS No.	2070015-22-2
Synonyms	OSUT315; OSU T315

Protocol	In Vitro	OSU-T315 (Compound 22; 0-5 μM; 24 hours) exhibits high in vitro potency against a panel of prostate and breast cancer cell lines with a IC50 range of 1-2.5 μM.
	In Vivo	OSU-T315 (Oral gavage; 25 mg/kg, 50 mg/kg; single daily; 35 days) has a suppressive effect of on PC-3 xenograft tumor growth.
	Animal model	Male NCr athymic nude mice with PC-3 tumor xenografts
	Dosages	25 mg/kg; 50 mg/kg
	Administration	Oral gavage; single daily; 35 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8741 mL	9.3705 mL	18.7410 mL	37.4820 mL
5mM	0.3748 mL	1.8741 mL	3.7482 mL	7.4964 mL
10mM	0.1874 mL	0.9370 mL	1.8741 mL	3.7482 mL
20mM	0.0937 mL	0.4685 mL	0.9370 mL	1.8741 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.