OSMI-1
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | Check With Us |
| 200mg | $1575 | Check With Us |
| 500mg | $2660 | Check With Us |
: Cat #: V6524 CAS #: 1681056-61-0 Purity ≥ 99%
Description: OSMI-1 (OSMI1; OSMI 1) is a novel, potent, cell permeable and quinolinone-6-sulfonamide-based inhibitor of O-GlcNAc transferase (OGT) with an IC50 value of 2.7 μM.
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| Molecular Weight (MW) | 563.64 |
|---|---|
| Molecular Formula | C28H25N3O6S2 |
| CAS No. | 1681056-61-0 |
| SMILES Code | O=C(N(CC1=CC=CO1)CC2=CC=CS2)[C@@H](C3=CC=CC=C3OC)NS(=O)(C4=CC5=C(NC(C=C5)=O)C=C4)=O |
| Synonyms | OSMI-1; OSMI 1; OSMI1; |
| Protocol | In Vitro | OSMI-1 (10-100 μM; 24 hours; CHO cells) treatment reduces global O-linked N-acetylglucosamine (O-GlcNAcylation) a dose-dependent manner. OSMI-1 inhibits OGT activity in cells. OSMI-1 (50 μM; 24 hours; CHO cells) treatment decreases the viability by about 50% after 24 hours. |
|---|---|---|
| In Vivo | Mammalian and zebrafish toxicity profiles are strikingly similar, and zebrafish can usually serve as an intermediate step between cell-based evaluation and conventional animal testing. The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC50 of OSM1-1 is 0.031 mg/mL (56 μM, 12 h) and 0.025 mg/mL (45 μM, 24 h) in zebrafish model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7742 mL | 8.8709 mL | 17.7418 mL | 35.4836 mL |
| 5mM | 0.3548 mL | 1.7742 mL | 3.5484 mL | 7.0967 mL |
| 10mM | 0.1774 mL | 0.8871 mL | 1.7742 mL | 3.5484 mL |
| 20mM | 0.0887 mL | 0.4435 mL | 0.8871 mL | 1.7742 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.