Osilodrostat (LCI699)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1350 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V2622 CAS #: 928134-65-0 Purity ≥ 98%
Description: Osilodrostat (LCI699; LCI-699; Isturisa) is a novel and potent inhibitor of 11β-hydroxylase and approved medication for the treatment of adults with Cushing's disease.
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| Molecular Weight (MW) | 227.24 |
|---|---|
| Molecular Formula | C13H10FN3 |
| CAS No. | 928134-65-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 45 mg/mL (198.0 mM)r |
| Water: 15 mg/mL (66.0 mM)r | |
| Ethanol: 45 mg/mL (198.0 mM) | |
| Solubility In Vivo | Chemical Name: (R)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile InChi Key: USUZGMWDZDXMDG-CYBMUJFWSA-N InChi Code: InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1 SMILES Code: N#CC1=CC=C([C@H]2CCC3=CN=CN32)C(F)=C1 |
| SMILES Code | N#CC1=CC=C([C@H]2CCC3=CN=CN32)C(F)=C1 |
| Synonyms | Osilodrostat; LCI699; Isturisa; LCI 699; LCI-699 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.4006 mL | 22.0032 mL | 44.0063 mL | 88.0127 mL |
| 5mM | 0.8801 mL | 4.4006 mL | 8.8013 mL | 17.6025 mL |
| 10mM | 0.4401 mL | 2.2003 mL | 4.4006 mL | 8.8013 mL |
| 20mM | 0.2200 mL | 1.1002 mL | 2.2003 mL | 4.4006 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.