Orphenadrine Citrate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $200 | Check With Us |
| 10g | $300 | Check With Us |
| 20g | $450 | Check With Us |
: Cat #: V1190 CAS #: 4682-36-4 Purity ≥ 98%
Description: Orphenadrine Citrate (BS-5930; BS5930; BS 5930; Disipal), the citrate salt of Orphenadrine, is an uncompetitive NMDA receptor antagonist and a potent skeletal muscle relaxant with antispastic and analgesic activities.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 461.5 |
|---|---|
| Molecular Formula | C18H23NO.C6H8O7 |
| CAS No. | 4682-36-4 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 92 mg/mL (199.3 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | CC1=CC=CC=C1C(OCCN(C)C)C2=CC=CC=C2.[H]Cl |
| Synonyms | BS 5930, BS5930, Orphenadrine Hydrochloride, BS-5930, Disipal, Orphenadrine HCl |
| Protocol | In Vitro | Orphenadrine citrate (12 µM; 24.5 h) shows neuroprotective effects on 3-NPA-induced neurotoxicity cerebellar granule cells |
|---|---|---|
| In Vivo | Orphenadrine citrate (10, 20, 30 mg/kg; i.p.; once aday for 3 days) reduces 3-NPA-induced mortality in a dose-dependent manner | |
| Animal model | Adult male Sprague Dawley rats (275-300 g; 3-NPA toxicity model) | |
| Dosages | 10, 20, 30 mg/kg | |
| Administration | Intraperitoneal injection; once aday for 3 days (30 min before 3-NPA) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1668 mL | 10.8342 mL | 21.6685 mL | 43.3369 mL |
| 5mM | 0.4334 mL | 2.1668 mL | 4.3337 mL | 8.6674 mL |
| 10mM | 0.2167 mL | 1.0834 mL | 2.1668 mL | 4.3337 mL |
| 20mM | 0.1083 mL | 0.5417 mL | 1.0834 mL | 2.1668 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.