Ornidazole Levo-

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Ornidazole Levo-
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$390Check With Us
2g$590Check With Us
5g$990Check With Us

Cat #: V3667 CAS #: 166734-83-4 Purity ≥ 98%

Description: Levo-Ornidazole [also known as (S)-Ornidazole; Levornidazole] is the levo-isomer of ornidazole which is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria. Levo-Ornidazole is the less active isomer. Ornidazole is a approved drug that cures some protozoan infections. It has been investigated for use in Crohn's disease after bowel resection. Synthesis is a straightforward reaction between 2-methyl-nitroimidazole and epichlorohydrin under acid catalyst conditions. After passive absorption into bacterium cell, the nitro group of ornidazole is reduced to amine group by ferrodoxin type redox system. The formation of redox intermediate intracellular metabolites is believed to be the key component of microorganism killing for Ornidazole. The drug is active against anaerobic bacteria viz. Peptostreptococcus, Clostridium, B. fragilis, Prevotella, Porphyronomas, Fusobacterium and protozoa viz. E. histolytica, T. vaginalis, G. intestinalis etc.

References: Guo B, et al. Clinical Pharmacokinetics of Levornidazole in Elderly Subjects and Dosing Regimen Evaluation Using Pharmacokinetic/Pharmacodynamic Analysis. Clin Ther. 2017 Jul;39(7):1336-1346.

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Molecular Weight (MW)219.625
Molecular FormulaC7H10ClN3O3
CAS No.166734-83-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeCC1=NC=C([N+]([O-])=O)N1C[C@H](O)CCl
Synonyms(S)-Ornidazole; Levornidazole; Ornidazole; NSC 95075; Ro 7-0207; Tiberal
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.5532 mL22.7661 mL45.5322 mL91.0643 mL
5mM0.9106 mL4.5532 mL9.1064 mL18.2129 mL
10mM0.4553 mL2.2766 mL4.5532 mL9.1064 mL
20mM0.2277 mL1.1383 mL2.2766 mL4.5532 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.