Oritavancin (LY333328)

This product is for research use only, not for human use. We do not sell to patients.

Oritavancin (LY333328)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$850To Be Confirmed
250mg$1350To Be Confirmed
500mg$2025To Be Confirmed

Cat #: V2170 CAS #: 171099-57-3 Purity ≥ 99%

Description: Oritavancin (formerly known as LY333328; LY-333328; Orbactiv) is a novel semisynthetic glycopeptide antibiotic medication approved for the treatment of serious Gram-positive bacterial infections. It is a lipoglycopeptide analog of vancomycin containing the heptapeptide core common to all glycopeptides. On August 6, 2014, the FDA approved oritavancin for treatment of skin infections. Oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, MRSA, enterococci, and streptococci. Oritavancin was more active than either metronidazole or vancomycin against strains of Clostridium difficile tested. Oritavancin has potential use as a therapy for exposure to Bacillus anthracis, the Gram-positive bacterium that causes anthrax, having demonstrated efficacy in a mouse model both before and after exposure to the bacterium. Reference: Oritavancin for the treatment of acute bacterial skin and skin structure infections: an evidence-based review. Core Evid. 2015 Feb 11;10:39-47.

References: [1]. Coyle EA, et al. Activity of oritavancin (LY333328), an investigational glycopeptide, compared to that of vancomycin against multidrug-resistant Streptococcus pneumoniae in an in vitro pharmacodynamic model. Antimicrob Agents Chemother. 2001 Mar;45(3):706-9.

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Molecular Weight (MW)1793.10
Molecular FormulaC86H97Cl3N10O26
CAS No.171099-57-3
SMILES CodeC[C@H]1[C@H](O)[C@@](C)(N)C[C@H](O[C@H]2[C@H]3C(N[C@H](C(O)=O)C4=CC(O)=CC(O)=C4C5=C(O)C=CC([C@@H](NC([C@H]6C7=CC(OC8=C(Cl)C=C2C=C8)=C(O[C@H]9[C@H](O[C@H]%10C[C@](C)(NCC%11=CC=C(C%12=CC=C(Cl)C=C%12)C=C%11)[C@@H](O)[C@H](C)O%10)[C@@H](O)[C@H](O)[C@@H](CO)O9)C(OC%13=C(Cl)C=C([C@@H](O)[C@@H](NC([C@H](NC)CC(C)C)=O)C(N[C@@H](CC(N)=O)C(N6)=O)=O)C=C%13)=C7)=O)C(N3)=O)=C5)=O)O1.O=P(O)(O)O.O=P(O)(O)O
SynonymsLY333328; Oritavancin; LY-333328; Oritavancin diphosphate; LY 333328;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM0.5577 mL2.7885 mL5.5769 mL11.1539 mL
5mM0.1115 mL0.5577 mL1.1154 mL2.2308 mL
10mM0.0558 mL0.2788 mL0.5577 mL1.1154 mL
20mM0.0279 mL0.1394 mL0.2788 mL0.5577 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.