Orexin 2 Receptor Agonist

This product is for research use only, not for human use. We do not sell to patients.

Orexin 2 Receptor Agonist
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1400Check With Us
500mg$1999Check With Us
1g$3000Check With Us

Cat #: V2946 CAS #: 1796565-52-0 Purity ≥ 98%

Description: Orexin 2 Receptor Agonist is a potent and selective Orexin2 receptor agonist with EC50 of 0.023 μM on OX2R; it is OX2R-selective (OX1R/OX2R EC50 ratio is 70).

References: Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015 Oct 22;58(20):7931-7.

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Product Promise

Promise
Molecular Weight (MW)586.70
Molecular FormulaC32H34N4O5S
CAS No.1796565-52-0
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 30 mg/mLr
Water: <1 mg/mLr
Ethanol: <1 mg/mL
SynonymsOrexin 2 Receptor Agonist
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7044 mL8.5222 mL17.0445 mL34.0890 mL
5mM0.3409 mL1.7044 mL3.4089 mL6.8178 mL
10mM0.1704 mL0.8522 mL1.7044 mL3.4089 mL
20mM0.0852 mL0.4261 mL0.8522 mL1.7044 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.