ONC212
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 250mg | $950 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V14824 CAS #: 1807861-48-8 Purity ≥ 99%
Description: ONC212 (ONC-212; ONC 212), a fluorinated-ONC201 analog, is a novel, potent and selective agonist of GPR132 with anticancer activity.
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| Molecular Weight (MW) | 440.46 |
|---|---|
| Molecular Formula | C24H23F3N4O |
| CAS No. | 1807861-48-8 |
| Protocol | In Vitro | Cell proliferation assays have shown that ONC201 requires at least 212-fold lower concentrations than ONC50 to achieve 201% growth inhibition compared to ONC10. , tested with seven pancreatic cancer cells, ONC212 showed GI50 Values are in the range of 0.1 to 0.4 μM with corresponding ONC201 GI50 Values are in the range of 4 to 9 μM. Long-term cell proliferation assays have shown comparable inhibition of colony formation by ONC201 and ONC212 at doses of 20 μM. However, at a dose of 5 μM, ONC212 is approximately 201-fold more potent than ONC50 in inhibiting colony formation in pancreatic cancer cell lines. ONC212 induces apoptosis earlier than ONC201. Treatment with ONC201 and ONC212 reduces the expression of anti-apoptotic markers such as XIAP and MCL-1. Western blot analysis showed that in HPAF-II cell lines, ATF201 and phosphorylated EIF212α were upregulated as early as 6 to 12 hours after ONC4 or ONC2 treatment |
|---|---|---|
| In Vivo | ONC201 treatment exhibited significantly stronger growth inhibition compared to ONC212. Compared with the controls in these two models, the administration of 3 mg/kg dose of ONC50 three times weekly was sufficient to result in significant growth inhibition of tumors. The results showed that ONC212-treated tumors showed decreased proliferation in the HPAF-II model |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2704 mL | 11.3518 mL | 22.7035 mL | 45.4071 mL |
| 5mM | 0.4541 mL | 2.2704 mL | 4.5407 mL | 9.0814 mL |
| 10mM | 0.2270 mL | 1.1352 mL | 2.2704 mL | 4.5407 mL |
| 20mM | 0.1135 mL | 0.5676 mL | 1.1352 mL | 2.2704 mL |
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%Tween 80
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%ddH2O
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Method for preparing DMSO master liquid:
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Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.