Onametostat (JNJ-64619178)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1040 | To Be Confirmed |
| 250mg | $1800 | To Be Confirmed |
| 500mg | $2700 | To Be Confirmed |
: Cat #: V4503 CAS #: 2086772-26-9 Purity ≥ 98%
Description: Onametostat (JNJ-64619178; JNJ64619178) is a novel, potent, selective and pseudo-irreversible PRMT5 (protein arginine methyltransferase 5) inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 483.36 |
|---|---|
| Molecular Formula | C22H23BrN6O2 |
| CAS No. | 2086772-26-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1 |
| Synonyms | JNJ-64619178; JNJ 64619178; JNJ64619178; Onametostat; |
| Protocol | In Vitro | Onametostat binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. Onametostat shows potent and broad inhibition of cellular growth. |
|---|---|---|
| In Vivo | Oral administration of Onametostat results in efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome, in several non-small cell lung cancer and small cell lung cancer cancer mouse xenograft models. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0689 mL | 10.3443 mL | 20.6885 mL | 41.3770 mL |
| 5mM | 0.4138 mL | 2.0689 mL | 4.1377 mL | 8.2754 mL |
| 10mM | 0.2069 mL | 1.0344 mL | 2.0689 mL | 4.1377 mL |
| 20mM | 0.1034 mL | 0.5172 mL | 1.0344 mL | 2.0689 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.