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Olopatadine HCl (ALO4943A; KW4679)

This product is for research use only, not for human use. We do not sell to patients.

Olopatadine HCl (ALO4943A; KW4679)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$550Check With Us
1g$890Check With Us
5g$2314Check With Us
email: [email protected]        [email protected]

Cat #: V1222 CAS #: 140462-76-6 Purity ≥ 98%

Description: Olopatadine HCl (Pataday; Patanase; KW-4679; ALO-4943A; ALO4943A; KW4679), the hydrochloride salt of olopatadine, is a 2nd-generation, selective histamine H1 receptor (IC50 of 559 μM for the release of histamine) antagonist and also a mast cell stabilizer used to treat itching associated with allergic conjunctivitis (eye allergies), it may also be used for the treatment of steroid rebound (red skin syndrome).

References: Tamura, T., et al., Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52.

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Molecular Weight (MW)373.87
Molecular FormulaC21H23NO3.HCl
CAS No.140462-76-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 75 mg/mL (200.6 mM)r
Water: 13 mg/mL (34.8 mM)r
Ethanol: 8 mg/mL (21.39 mM)
SynonymsALO4943A; KW-4679; ALO-4943A; KW4679; Olopatadine HCl; Olopatadine Hydrochloride; Pataday; Patanase; KW 4679; ALO 4943A; ALO4943A
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6747 mL13.3736 mL26.7473 mL53.4945 mL
5mM0.5349 mL2.6747 mL5.3495 mL10.6989 mL
10mM0.2675 mL1.3374 mL2.6747 mL5.3495 mL
20mM0.1337 mL0.6687 mL1.3374 mL2.6747 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.