Olodaterol | CAS 868049-49-4

Olodaterol

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1150	Check With Us
500mg	$1850	Check With Us
1g	$2775	Check With Us

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Cat #: V13861 CAS #: 868049-49-4 Purity ≥ 98%

Description: Olodaterol (formerly known as BI-1744; BI1744; STRIVERDI RESPIMAT) is a ultra-long acting beta-adrenoceptor agonist approved in 2014 for use as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD) It was developed and manufactured by Boehringer-Ingelheim.

References: Herrmann FE, et al. Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis. Br J Pharmacol. 2017;174(21):3848-3864.

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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	386.44
Molecular Formula	C21H26N2O5
CAS No.	868049-49-4

Protocol	In Vitro	Olodaterol (0.001~1000 nM; 30 minutes; fibroblasts) increases intracellular cAMP in a concentration-dependent manner. Olodaterol (0~10 nM; 30 minutes; fibroblasts) concentration-dependently inhibits the PICP increase with maximal efficacy of 70 % at 10 nM. Olodaterol has a subnanomolar affinity for the β2-AR (pKi=9.14) and is selective for this receptorin comparison with the β1-AR and β3-AR subtypes
Protocol	In Vivo	Olodaterol (1 mg/kg; inhal.; 21 days) accelerats body weight recovery back to control levels (at day 21) and attenuats TGF-β-induced lung fibrosis

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5877 mL	12.9386 mL	25.8772 mL	51.7545 mL
5mM	0.5175 mL	2.5877 mL	5.1754 mL	10.3509 mL
10mM	0.2588 mL	1.2939 mL	2.5877 mL	5.1754 mL
20mM	0.1294 mL	0.6469 mL	1.2939 mL	2.5877 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.