OAC1 (BAS 00287861)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$750	Check With Us
500mg	$1200	Check With Us
1g	$1800	Check With Us

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Cat #: V1955 CAS #: 300586-90-7 Purity ≥ 98%

Description: OAC-1 (also known as BAS 00287861) is an Oct-4 (Octamer-binding transcription factor-4) activator which enhances and accelerates iPSC reprogramming in the presence of 4F (Oct-4, Sox-2, c-Myc and GKLF) by ~20-fold (relative to 4F by itself).

References: Li W, et, al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	237.26
Molecular Formula	C14H11N3O
CAS No.	300586-90-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 47 mg/mL (198.1 mM)r
	Water: <1 mg/mLr
	Ethanol: 21 mg/mL (88.5 mM)
Synonyms	BAS-00287861; BAS00287861; BAS 00287861; OAC 1; OAC1; OAC-1

Protocol	In Vitro	OAC1 (10 μM; 7 d) enhances reprogramming efficiency. OAC1 increases induced pluripotent stem cells (iPSC) generation from mouse embryonic fibroblasts (MEFs) and accelerates the appearance of iPSC-like colonies
	In Vivo	OAC1 (50000 CB CD34+ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice
	Animal model	Irradiated NSG mice with OAC1 or vehicle control treated CB CD34+ cells within 24h after irradiation
	Dosages	16 weeks
	Administration	Subcutaneous injection OAC1(500 nM) treated CB CD34+ cells

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.2148 mL	21.0739 mL	42.1479 mL	84.2957 mL
5mM	0.8430 mL	4.2148 mL	8.4296 mL	16.8591 mL
10mM	0.4215 mL	2.1074 mL	4.2148 mL	8.4296 mL
20mM	0.2107 mL	1.0537 mL	2.1074 mL	4.2148 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.