NVP-TNKS656
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1650 | Check With Us |
| 250mg | $2650 | Check With Us |
| 500mg | $3975 | Check With Us |
: Cat #: V1494 CAS #: 1419949-20-4 Purity ≥ 98%
Description: NVP-TNKS656 (also called TNKS-656; NVP-TNKS-656; TNKS 656; NVP-TNKS 656) is a selective, and orally bioactive tankyrase inhibitor with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 494.58 |
|---|---|
| Molecular Formula | C27H34N4O5 |
| CAS No. | 1419949-20-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (202.2 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: 10 mg/mL (20.2 mM) | |
| Solubility In Vivo | Chemical Name: N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide SMILES Code: O=C1NC(CN(CC2CC2)C(CN3CCC(C(C4=CC=C(OC)C=C4)=O)CC3)=O)=NC5=C1COCC5 |
| Synonyms | NVPTNKS-656; TNKS-656; NVP-TNKS656; TNKS 656; NVP-TNKS 656; TNKS656 |
| Protocol | In Vivo | NVP-TNKS656 (30 or 100 mg/kg, p.o.) exhibits good exposure and moderate oral bioavailability of 32% and 53%, respectively. Some slight overproportional increase in oral exposure is observed between 30 and 100 mg/kg with the dose normalized AUC for the 100 mg/kg dose being 2-fold higher than for the 30 mg/kg dose. Mice treated with NVP-TNKS656 (350 mg/kg, p.o.) show good plasma and tumor exposures corresponding to AUC0-24h of 515 and 325 μM·h, respectively |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0219 mL | 10.1096 mL | 20.2192 mL | 40.4384 mL |
| 5mM | 0.4044 mL | 2.0219 mL | 4.0438 mL | 8.0877 mL |
| 10mM | 0.2022 mL | 1.0110 mL | 2.0219 mL | 4.0438 mL |
| 20mM | 0.1011 mL | 0.5055 mL | 1.0110 mL | 2.0219 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.