NVP-BVU972
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1050 | Check With Us |
| 250mg | $1650 | Check With Us |
| 500mg | $2475 | Check With Us |
: Cat #: V0597 CAS #: 1185763-69-2 Purity ≥ 98%
Description: NVP-BVU972 (also names as BVN972; BVN-972) is a novel c-Met inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 340.38 |
|---|---|
| Molecular Formula | C20H16N6 |
| CAS No. | 1185763-69-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 68 mg/mL (199.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 68 mg/mL (199.8 mM) | |
| SMILES Code | CN1N=CC(C2=NN3C(C=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)=C1 |
| Synonyms | NVP-BVU-972; BVU-972; NVP-BVU972; NVP-BVU 972; BVU 972; BVU972. |
| Protocol | In Vitro | NVP-BVU972 (0-10 µM; 2 h) reduces TPR-MET phosphorylation in a dose-dependent manner in BaF3 TPR-MET cells. NVP-BVU972 (600 nM-9.6 µM; 72 h) shows good antiproliferative activity to BaF3 cells with MET mutations. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9379 mL | 14.6895 mL | 29.3789 mL | 58.7579 mL |
| 5mM | 0.5876 mL | 2.9379 mL | 5.8758 mL | 11.7516 mL |
| 10mM | 0.2938 mL | 1.4689 mL | 2.9379 mL | 5.8758 mL |
| 20mM | 0.1469 mL | 0.7345 mL | 1.4689 mL | 2.9379 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.