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NVP-ADW742

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NVP-ADW742
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Size Price Stock
250mg$1250Check With Us
500mg$1850Check With Us
1g$2775Check With Us
email: [email protected]        [email protected]

Cat #: V0624 CAS #: 475488-23-4 Purity ≥ 98%

Description: NVP-ADW742 (also known as ADW-742; ADW 742; GSK552602A; GSK-552602A) is a novel, potent and selective IGF-1R inhibitor with potential antitumor activity.

References: Mitsiades CS, et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell. 2004 Mar;5(3):221-30.

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Molecular Weight (MW)453.58
Molecular FormulaC28H31N5O
CAS No.475488-23-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mg/mL (22.0 mM)r
Water: <1 mg/mLr
Ethanol: 3 mg/mL (6.6 mM)
SMILES CodeNC1=C2C(N([C@H]3C[C@H](CN4CCCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
SynonymsGSK 552602A, ADW742; NVP-ADW742; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; GSK-552602A; GSK552602A;
ProtocolIn VitroNVP-ADW742 (0.1-9 µM; 20 min) blocks IGF-1-induced phosphorylation of IGF-1R and its known downstream target Akt at submicromolar concentrations. NVP-ADW742 has much higher IC50 values for other kinases (IC50>10 μM for HER2, PDGFR, VEGFR-2, or Bcr-Abl p210; and IC50>5 μM for c-Kit). NVP-ADW742 (ADW742; 0.1-10 µM; 72 hours) dose-dependently inhibits serum-induced cell growth in all cell lines.
In VivoNVP-ADW742 (ADW742; 10 mg/kg for IP or 50 mg/kg for orally; twice daily for 19 days) significantly suppresses tumor growth and prolongs the survival of mice.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2047 mL11.0234 mL22.0468 mL44.0937 mL
5mM0.4409 mL2.2047 mL4.4094 mL8.8187 mL
10mM0.2205 mL1.1023 mL2.2047 mL4.4094 mL
20mM0.1102 mL0.5512 mL1.1023 mL2.2047 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
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C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.