NVP-231
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $420 | Check With Us |
| 500mg | $630 | Check With Us |
| 1g | $945 | Check With Us |
: Cat #: V4640 CAS #: 362003-83-6 Purity ≥ 98%
Description: NVP-231 is a novel, potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK with IC50 of 12±2 nM.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 431.55 |
|---|---|
| Molecular Formula | C25H25N3O2S |
| CAS No. | 362003-83-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(C1(C2)C[C@H]3C[C@@H]2C[C@H](C3)C1)NC4=CC=C5N=C(NC(C6=CC=CC=C6)=O)SC5=C4 |
| Synonyms | NVP 231; NVP-231; NVP231 |
| Protocol | In Vitro | NVP-231 (0-500 nM; 24 hours) gradually reduces the cellular CerK activity, as measured by NBD-C1P formation, demonstrating that NVP-231 active in transfected cells. The IC50 for CerK in this cellular system is 59.70 ± 12 nM. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3172 mL | 11.5861 mL | 23.1723 mL | 46.3446 mL |
| 5mM | 0.4634 mL | 2.3172 mL | 4.6345 mL | 9.2689 mL |
| 10mM | 0.2317 mL | 1.1586 mL | 2.3172 mL | 4.6345 mL |
| 20mM | 0.1159 mL | 0.5793 mL | 1.1586 mL | 2.3172 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.