This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 1mg | $450 | 3-6 Days |
: Cat #: V40954 CAS #: 1258984-36-9 Purity ≥ 99%
Description: Nusinersen (Spinraza) is an FDA-approved medication used in the treatment of spinal muscular atrophy, a rare neuromuscular disorder. It is an antisense oligo(ribo)nucleotide (ASO) that is able to induce survival of motor neuron (SMN) expression. In December 2016, it became the first approved drug used in treating this disorder. Nusinersen cost US$750,000 in the first year and US$375,000 annually after that in the United States as of 2019.
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| Molecular Weight (MW) | 7127.1942691803 |
|---|---|
| Molecular Formula | C234H340N61O128P17S17 |
| CAS No. | 1258984-36-9 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.1403 mL | 0.7015 mL | 1.4031 mL | 2.8062 mL |
| 5mM | 0.0281 mL | 0.1403 mL | 0.2806 mL | 0.5612 mL |
| 10mM | 0.0140 mL | 0.0702 mL | 0.1403 mL | 0.2806 mL |
| 20mM | 0.0070 mL | 0.0351 mL | 0.0702 mL | 0.1403 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.