NU1025
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1050 | Check With Us |
| 500mg | $1650 | Check With Us |
| 1g | $2470 | Check With Us |
: Cat #: V0308 CAS #: 90417-38-2 Purity ≥ 98%
Description: NU1025 is a novel, potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP) inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 176.17 |
|---|---|
| Molecular Formula | C9H8N2O2 |
| CAS No. | 90417-38-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 35 mg/mL (198.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 6 mg/mL warmed (34.1 mM) | |
| Solubility In Vivo | 40% PEG 400+saline: 18mg/mL |
| Synonyms | Synonym: NU 1025; NU1025; NU-1025. Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolinone InChi Key: YJDAOHJWLUNFLX-UHFFFAOYSA-N InChi Code: InChI=1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13) SMILES Code: O=C1NC(C)=NC2=C1C=CC=C2O |
| Protocol | In Vitro | NU1025 (0.2 mM) pretreatment restores cell viability to approximately 73% and 82% in H2O2 and SIN-1 injured cells, respectively |
|---|---|---|
| In Vivo | NU1025 (1-3 mg/kg; intraperitoneal injection; male Sprague Dawley rats) treatment at 1 and 3 mg/kg reduces total infarct volume to 25% and 45%, respectively, when administered 1 h before reperfusion. NU1025 also produces significant improvement in neurological deficits. Neuroprotection with NU1025 is associated with reduction in PAR accumulation, reversal of brain NAD depletion and reduction in DNA fragmentation | |
| Animal model | Male Sprague Dawley rats (250-270 g) induced focal cerebral ischemia | |
| Dosages | 1 mg/kg, 3 mg/kg | |
| Administration | Intraperitoneal injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.6763 mL | 28.3817 mL | 56.7634 mL | 113.5267 mL |
| 5mM | 1.1353 mL | 5.6763 mL | 11.3527 mL | 22.7053 mL |
| 10mM | 0.5676 mL | 2.8382 mL | 5.6763 mL | 11.3527 mL |
| 20mM | 0.2838 mL | 1.4191 mL | 2.8382 mL | 5.6763 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.