NSC 405020
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $900 | Check With Us |
| 1g | $1400 | Check With Us |
| 5g | $3545 | Check With Us |
: Cat #: V0736 CAS #: 7497-07-6 Purity ≥ 99%
Description: NSC 405020 (NSC405020; NSC-405020) is a novel small molecule inhibitor of MT1-MMP (Membrane type-1 matrix metalloproteinase) that targets the noncatalytic domain of MMP with potential antineoplastic activity.
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| Molecular Weight (MW) | 260.16 |
|---|---|
| Molecular Formula | C12H15Cl2NO |
| CAS No. | 7497-07-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 52 mg/mL (199.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 52 mg/mL (199.9 mM) | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 5 mg/mL |
| SMILES Code | O=C(NC(C)CCC)C1=CC=C(Cl)C(Cl)=C1 |
| Synonyms | NSC 405020; NSC405020; NSC-405020; |
| Protocol | In Vitro | NSC 405020 (100 and 1000 μM; 0-30 min) inhibits MMP-14 levels by over 85% with a dose-dependent manner in the plasma sample from vestibular schwannoma group. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.8438 mL | 19.2189 mL | 38.4379 mL | 76.8758 mL |
| 5mM | 0.7688 mL | 3.8438 mL | 7.6876 mL | 15.3752 mL |
| 10mM | 0.3844 mL | 1.9219 mL | 3.8438 mL | 7.6876 mL |
| 20mM | 0.1922 mL | 0.9609 mL | 1.9219 mL | 3.8438 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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Concentration(final)
C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.