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NSC-305787 HCl

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NSC-305787 HCl
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Cat #: V5038 CAS #: 53868-26-1 Purity ≥ 98%

Description: NSC305787 HCl, the hydrochloride salt of NSC305787, is a novel, potent and selective small molecule inhibitor of ezrin with a Kd of 5.85 μM, it inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, and has antitumor activity. Ezrin is a key driver of tumor progression and metastatic spread of osteosarcoma. NSC-305787 HCl directly binds to ezrin and inhibits its functions in promoting invasive phenotype. NSC-305787 HCl reduces the incidence of lung metastasis in a genetically engineered mouse model of osteosarcoma.

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CAS No.53868-26-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.