NS3861
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $450 | To Be Confirmed |
| 250mg | $800 | To Be Confirmed |
| 500mg | $1200 | To Be Confirmed |
: Cat #: V26678 CAS #: 216853-60-0 Purity ≥ 99%
Description: NS-3861 is a novel and potent α3β2 nAChR full agonist and an α3β4 partial agonist (Ki = 0.62 nM).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
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| Molecular Weight (MW) | 400.28 |
|---|---|
| Molecular Formula | C16H18BrNO4S |
| CAS No. | 216853-60-0 |
| Synonyms | NS 3861; NS-3861 |
| Protocol | In Vitro | NS3861 fumarate displays the opposite β-subunit preference and a complete lack of activation at α4-containing receptors in HEK293 cell lines. NS3861 fumarate selectively activates α3- but not α4-containing nAChRs and it displays higher efficacy at the α3β2 receptor compared with the α3β4 receptor, with EC50s of 1.7 and 0.15 μM for α3β2 and α3β4 receptor, respectively. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4983 mL | 12.4913 mL | 24.9825 mL | 49.9650 mL |
| 5mM | 0.4997 mL | 2.4983 mL | 4.9965 mL | 9.9930 mL |
| 10mM | 0.2498 mL | 1.2491 mL | 2.4983 mL | 4.9965 mL |
| 20mM | 0.1249 mL | 0.6246 mL | 1.2491 mL | 2.4983 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.