NQN-1 (PPM-18)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1050	To Be Confirmed
500mg	$1650	To Be Confirmed
1g	$2475	To Be Confirmed

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Cat #: V5303 CAS #: 65240-86-0 Purity ≥ 98%

Description: NQN-1 (PPM-18), a chemically synthesized naphthoquinone derivative and an anti-inflammatory agent, is a novel, potent and cell-permeable and anti-inflammatory agent shown to express inhibitory effects of iNOS through the blocking of NF kappa B activation in vitro.

References: S M Yu, et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):363-9.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	277.27
Molecular Formula	C17H11NO3
CAS No.	65240-86-0
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C(C1=C2C=CC=C1)C=C(NC(C3=CC=CC=C3)=O)C2=O
Synonyms	NQN-1; NQN-1; NQN-1;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.6066 mL	18.0330 mL	36.0659 mL	72.1319 mL
5mM	0.7213 mL	3.6066 mL	7.2132 mL	14.4264 mL
10mM	0.3607 mL	1.8033 mL	3.6066 mL	7.2132 mL
20mM	0.1803 mL	0.9016 mL	1.8033 mL	3.6066 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.