NP118809
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $200 | Check With Us |
| 1g | $320 | Check With Us |
| 5g | $864 | Check With Us |
: Cat #: V26632 CAS #: 41332-24-5 Purity ≥ 99%
Description: NP-118809 is a N-type calcium channel blocker.
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| Molecular Weight (MW) | 460.621 |
|---|---|
| Molecular Formula | C32H32N2O |
| CAS No. | 41332-24-5 |
| Synonyms | 39-1B4; NP 118809; NP-118809; NP118809; Z160; Z160; Z160. |
| Protocol | In Vitro | NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM |
|---|---|---|
| In Vivo | NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1710 mL | 10.8549 mL | 21.7098 mL | 43.4196 mL |
| 5mM | 0.4342 mL | 2.1710 mL | 4.3420 mL | 8.6839 mL |
| 10mM | 0.2171 mL | 1.0855 mL | 2.1710 mL | 4.3420 mL |
| 20mM | 0.1085 mL | 0.5427 mL | 1.0855 mL | 2.1710 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.