Nosiheptide
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $850 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V21062 CAS #: 56377-79-8 Purity ≥ 99%
Description: Nosiheptide is a parent compound of thiopeptide family that exhibit potent activities against various bacterial pathogens.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 1222.36 |
|---|---|
| Molecular Formula | C51H43N13O12S6 |
| CAS No. | 56377-79-8 |
| SMILES Code | C/C=C1NC([C@H]([C@H](O)C)NC(C2csC(c3c(C4csC([C@@H]5CSC(c([nH]6)c(C)c7c6cccc7COC([C@H](C[C@@H](C8[N]C(C(N5)=O)cs8)NC(C9csC\1[N]9)=O)O)=O)=O)[N]4)nc(c%10scc(C(NC(C(N)=O)=C)=O)n%10)c(O)c3)[N]2)=O)=O |
| Synonyms | RP 9671; RP-9671; RP9671; Nosiheptide; Multhiomycin; Multiomycin; Nosiheptidum |
| Protocol | In Vitro | Nosiheptide exhibits extremely potent activity against all contemporary Staphylococcus aureus strains tested including multiple drug-resistant clinical isolates, with MIC values ≤ 0.25 mg/L. Nosiheptide is also highly active against Enterococcus spp and the contemporary hypervirulent BI strain of Clostridium difficile but is inactive against most Gram-negative strains tested. Time-kill analysis reveals Nosiheptide to be rapidly bactericidal against Staphylococcus aureus in a concentration- and time-dependent manner, with a nearly 2-log kill noted at 6 hours at 10X MIC. Furthermore, Nosiheptide is found to be non-cytotoxic against mammalian cells at >> 100X MIC, and its anti-Staphylococcus aureus activity is not inhibited by 20% human serum. Notably, Nosiheptide exhibits a significantly prolonged post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus compared to vancomycin. |
|---|---|---|
| In Vivo | Nosiheptide (20 mg/kg; intraperitoneal injection; injected at 1 and 8 h post-infection; female CD1 mice) provids significant protection against mortality. Ten out of 10 of the Nosiheptide-treated mice remains alive on day 3, while 6/10 of the controls died on day 1. | |
| Animal model | Eight week old female CD1 mice injected with HA-Staphylococcus aureus strain Sanger 252 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.8181 mL | 4.0904 mL | 8.1809 mL | 16.3618 mL |
| 5mM | 0.1636 mL | 0.8181 mL | 1.6362 mL | 3.2724 mL |
| 10mM | 0.0818 mL | 0.4090 mL | 0.8181 mL | 1.6362 mL |
| 20mM | 0.0409 mL | 0.2045 mL | 0.4090 mL | 0.8181 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.