Norfloxacin hydrochloride (MK-0366)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100g | $600 | Check With Us |
| 200g | $850 | Check With Us |
| 500g | $1430 | Check With Us |
: Cat #: V29651 CAS #: 68077-27-0 Purity ≥ 99%
Description: Norfloxacin hydrochloride (MK-0366) is a broad-spectrum and synthetic chemotherapeutic antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.
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| Molecular Weight (MW) | 355.79 |
|---|---|
| Molecular Formula | C16H19ClFN3O3 |
| CAS No. | 68077-27-0 |
| SMILES Code | CCN1C=C(C(c2c1cc(N3CCNCC3)c(F)c2)=O)C(O)=O.Cl |
| Synonyms | Norfloxacin HCl; Norfloxacin hydrochloride; |
| Protocol | In Vitro | Norfloxacin hydrochloride (MK-0366 hydrochloride) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8106 mL | 14.0532 mL | 28.1065 mL | 56.2129 mL |
| 5mM | 0.5621 mL | 2.8106 mL | 5.6213 mL | 11.2426 mL |
| 10mM | 0.2811 mL | 1.4053 mL | 2.8106 mL | 5.6213 mL |
| 20mM | 0.1405 mL | 0.7027 mL | 1.4053 mL | 2.8106 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.