Nobiletin

This product is for research use only, not for human use. We do not sell to patients.

Nobiletin
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$750Check With Us
1g$1200Check With Us
5g$3035Check With Us

Cat #: V0738 CAS #: 478-01-3 Purity ≥ 98%

Description: Nobiletin (Hexamethoxyflavone; NOB), a naturally occurring flavonoid compound isolated from citrus peels like in tangerine and the Chinese drug chen-pi, has anti-inflammatory and anti-tumor activities.

References: Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Jun 7;7(23):35208-23.

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Product Promise

Promise
Molecular Weight (MW)402.39
Molecular FormulaC21H22O8
CAS No.478-01-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 81 mg/mL (201.3 mM)r
Water: <1 mg/mLr
Ethanol: 3 mg/mL (7.5 mM)
SMILES CodeO=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C1C(OC)=C(OC)C(OC)=C3OC
SynonymsNobiletin; Hexamethoxyflavone; NOB;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4852 mL12.4258 mL24.8515 mL49.7030 mL
5mM0.4970 mL2.4852 mL4.9703 mL9.9406 mL
10mM0.2485 mL1.2426 mL2.4852 mL4.9703 mL
20mM0.1243 mL0.6213 mL1.2426 mL2.4852 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.