NLRP3-IN-10

This product is for research use only, not for human use. We do not sell to patients.

NLRP3-IN-10
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10mg$80To Be Confirmed
50mg$230To Be Confirmed
100mg$360To Be Confirmed
email: [email protected]        [email protected]

Cat #: V42295 CAS #: 2641826-39-1 Purity ≥ 99%

Description: NLRP3-IN-10 is a potent NLRP3 inhibitor (antagonist) with IC50 of 251.1 nM for IL-1β inhibition. NLRP3-IN-10 can attenuate ASC speck formation and inhibit NLRP3 inflammasome activation.

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Molecular Weight (MW)365.19
Molecular FormulaC17H14BRFO3
CAS No.2641826-39-1
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7383 mL13.6915 mL27.3830 mL54.7660 mL
5mM0.5477 mL2.7383 mL5.4766 mL10.9532 mL
10mM0.2738 mL1.3692 mL2.7383 mL5.4766 mL
20mM0.1369 mL0.6846 mL1.3692 mL2.7383 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.