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Niraparib Tosylate (MK-4827)

This product is for research use only, not for human use. We do not sell to patients.

Niraparib Tosylate (MK-4827)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$350In Stock
500mg$500In Stock
1g$750In Stock
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Cat #: V3043 CAS #: 1038915-73-9 Purity ≥ 98%

Description: Niraparib Tosylate (also known as MK-4827; MK4827; Zejula), the tosylate salt of niraparib, is an orally bioavailable and selective inhibitor of PARP1/2 (IC50 = 3.8 nM and 2.1nM) that gained FDA approval in March 2017 for the treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer.

References: Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.

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Molecular Weight (MW)492.59
Molecular FormulaC26H28N4O4S
CAS No.1038915-73-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ~500mg/mLr
Water: <1mg/mLr
Ethanol: <1mg/mL
SynonymsMK-4827 tosylate; MK 4827; MK4827 tosylate; MK 4827 tosylate; MK-4827; MK4827; Niraparib; Niraparib HCl; Niraparib hydrochloride; Zejula Chemical Name: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrochloride Exact Mass: 356.1404
ProtocolIn VitroNiraparib (MK-4827) inhibits PARP activity with EC50=4 nM and EC90=45 nM in a whole cell assay. MK-4827 inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10−100 nM range. MK-4827 displays excellent PARP 1 and 2 inhibition with IC50=3.8 and 2.1 nM, respectively, and in a whole cell assay
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.0301 mL10.1504 mL20.3009 mL40.6017 mL
5mM0.4060 mL2.0301 mL4.0602 mL8.1203 mL
10mM0.2030 mL1.0150 mL2.0301 mL4.0602 mL
20mM0.1015 mL0.5075 mL1.0150 mL2.0301 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.