Nimorazole | CAS 6506-37-2

Nimorazole

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$300	Check With Us
1g	$480	Check With Us
5g	$1215	Check With Us

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Cat #: V2843 CAS #: 6506-37-2 Purity ≥ 98%

Description: Nimorazole,a nitroimidazole anti-infective, is a hypoxic radiosensitizer potentially useful in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Nimorazole significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be given without major side-effects. Nimorazole is the only such chemical reagent that has shown a significant effect in a randomized controlled trial in head and neck cancer.

References: Peter Wardman, et al. Nitroimidazoles as hypoxic cell radiosensitizers and hypoxia probes: misonidazole, myths and mistakes. Br J Radiol. 2019 Jan;92(1093):20170915.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	226.23
Molecular Formula	C9H14N4O3
CAS No.	6506-37-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >30 mg/mLr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	O=[N+](C1=CN=CN1CCN2CCOCC2)[O-]
Synonyms	Nimorazole; K-1900; K 1900; K1900

Protocol	In Vitro	In vitro activity: Nimorazole,a nitroimidazole anti-infective, is a hypoxic radiosensitizer potentially useful in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Nimorazole significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be given without major side-effects. Nimorazole is the only such chemical reagent that has shown a significant effect in a randomized controlled trial in head and neck cancer.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.4203 mL	22.1014 mL	44.2028 mL	88.4056 mL
5mM	0.8841 mL	4.4203 mL	8.8406 mL	17.6811 mL
10mM	0.4420 mL	2.2101 mL	4.4203 mL	8.8406 mL
20mM	0.2210 mL	1.1051 mL	2.2101 mL	4.4203 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.