Nicardipine HCl (RS69216; YC93; Antagonil, Dagan, Flusemide)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $200 | Check With Us |
| 10g | $350 | Check With Us |
| 20g | $525 | Check With Us |
: Cat #: V0748 CAS #: 54527-84-3 Purity ≥ 98%
Description: Nicardipine HCl (formerly YC-93, RS-69216; YC93; trade names Cardene, Dagan, Antagonil, Flusemide), the hydrochloride salt of nicardipine, is a dihydropyridine/DHP class of calcium-channel blocker (CCB) with anti-hypertensive activity.
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| Molecular Weight (MW) | 515.99 |
|---|---|
| Molecular Formula | C26H29N3O6.HCl |
| CAS No. | 54527-84-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (193.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | Nicardipine HCl; YC 93; YC93; Cardene, RS69216; Nicardipine Hydrochloride; RS-69216; RS 69216; YC-93; Antagonil, Dagan, Flusemide |
| Protocol | In Vitro | Nicardipine (0.1-10 μM; 24-48 h) reduces viability and proliferation of vascular smooth muscle cells (VSMCs) and inhibits their ability to migrate |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9380 mL | 9.6901 mL | 19.3802 mL | 38.7604 mL |
| 5mM | 0.3876 mL | 1.9380 mL | 3.8760 mL | 7.7521 mL |
| 10mM | 0.1938 mL | 0.9690 mL | 1.9380 mL | 3.8760 mL |
| 20mM | 0.0969 mL | 0.4845 mL | 0.9690 mL | 1.9380 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.