Neuraminidase-IN-1

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1250	Check With Us
500mg	$1950	Check With Us
1g	$2925	Check With Us

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Cat #: V2221 CAS #: 2379438-80-7 Purity ≥ 99%

Description: Neuraminidase-IN-1， also known as Y-1, is a neuraminidase inhibitor, with an IC50 of 0.21 μM. Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus and good inhibitory effect on the A/WSN/33 H1N1 virus strains.Y-1 exerts the best inhibition activity (IC50 = 0.21 μM) against NA, which is better than oseltamivir carboxylate (OSC) (IC50 = 3.04 μM) and lead AN-329/10738021 (IC50 = 1.92 μM).

References: [1]. Cheng, Liping, et al. Preparation of dihydroxybenzoylhydrazone neuraminidase inhibitor used in preparation of drugs for resisting H1N1 influenza virus. CN109776354A.

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Molecular Weight (MW)	317.257
Molecular Formula	C14H11N3O6
CAS No.	2379438-80-7
SMILES Code	O=C(N/N=C/C1=CC=C(O)C([N+]([O-])=O)=C1)C2=CC(O)=CC(O)=C2
Synonyms	Y-1; Y1; Y 1; Neuraminidase-IN-1

Protocol	In Vitro	Neuraminidase-IN-1 has good inhibitory effect on the A/WSN/33H1N1 virus strains, with low toxicity and good druggability.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1520 mL	15.7601 mL	31.5202 mL	63.0404 mL
5mM	0.6304 mL	3.1520 mL	6.3040 mL	12.6081 mL
10mM	0.3152 mL	1.5760 mL	3.1520 mL	6.3040 mL
20mM	0.1576 mL	0.7880 mL	1.5760 mL	3.1520 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.