Netilmicin Sulfate (SCH-20569)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$650	Check With Us
500mg	$1150	Check With Us
1g	$1725	Check With Us

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Cat #: V2320 CAS #: 56391-57-2 Purity ≥ 98%

Description: Netilmicin Sulfate, a semisynthetic and water soluble analog of sisomicin, is a member of the aminoglycoside family of antibiotics. It is active against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin. Netilmicin Sulfate is a semisynthetic derivative of sisomicin. It shows activity against aminoglycoside-resistant bacteria and much decreased chronic toxicity in animals relative to sisomicin, gentamicin and tobramycin. Netilmicin Sulfate shows high activity against E. coli, Klebsiella, Enterobacter, Citrobacter, Proteus spp and Staph. Aureus. In addition, 87% of indole-positive Proteus strains, 90.7% of Serratia and 83.5% of Ps. Aeruginosa strains are sensitive to Netilmicin Sulfate.

References: [1]. Campoli-Richards DM, et al. Netilmicin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1989 Nov;38(5):703-56.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1441.55
Molecular Formula	C21H41N5O7.2.5H2O4S
CAS No.	56391-57-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: <1 mg/mLr
	Water: 288 mg/mL (199.8 mM)r
	Ethanol: <1 mg/mL
SMILES Code	O[C@H]1[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@@H]3[C@H](N)CC=C(CN)O3)[C@@H](N)C[C@H]2NCC)OC[C@@](O)(C)[C@@H]1NC.O=S(O)(O)=O
Synonyms	Sch-20569; Sch 20569; Sch 20569

Protocol	In Vitro	In vitro activity: Netilmicin Sulfate is a semisynthetic derivative of sisomicin. It shows activity against aminoglycoside-resistant bacteria and much decreased chronic toxicity in animals relative to sisomicin, gentamicin and tobramycin. Netilmicin Sulfate shows high activity against E. coli, Klebsiella, Enterobacter, Citrobacter, Proteus spp and Staph. Aureus. In addition, 87% of indole-positive Proteus strains, 90.7% of Serratia and 83.5% of Ps. Aeruginosa strains are sensitive to Netilmicin Sulfate.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.6937 mL	3.4685 mL	6.9370 mL	13.8740 mL
5mM	0.1387 mL	0.6937 mL	1.3874 mL	2.7748 mL
10mM	0.0694 mL	0.3468 mL	0.6937 mL	1.3874 mL
20mM	0.0347 mL	0.1734 mL	0.3468 mL	0.6937 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.