Neohesperidin dihydrochalcone
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $600 | Check With Us |
| 100g | $980 | Check With Us |
| 200g | $1470 | Check With Us |
: Cat #: V31815 CAS #: 20702-77-6 Purity ≥ 99%
Description: Neohesperidin dihydrochalcone (Neohesperidin DC; NHDC), an artificial sweetener and a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.
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- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 612.58 |
|---|---|
| Molecular Formula | C28H36O15 |
| CAS No. | 20702-77-6 |
| SMILES Code | COC1=C(O)C=C(CCC(C2=C(O)C=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3OC4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)C=C2O)=O)C=C1 |
| Synonyms | Neohesperidin dihydrochalcone; Neohesperidin DC; NHDC |
| Protocol | In Vitro | Neohesperidin dihydrochalcone shows remarkable radical scavenging activity against stable radical and reactive oxygen species (ROS) in concentration dependent manner. Especially, neohesperidin dihydrochalcone is the most potent inhibitor of H2O2 and HOCl. Neohesperidin dihydrochalcone shows HOCl scavenging activity of 93.5% and H2O2 scavenging property of 73.5%. Neohesperidin dihydrochalcone shows extensive inhibitory effect especially on non-radical ROS H2O2 and HOCl with IC50 values of 205.1, 25.5 μM. |
|---|---|---|
| In Vivo | Neohesperidin dihydrochalcone administration results in significant reduction in activities of two useful markers of liver damage, AST and ALT. The relative levels of NF-κB, IL-6, IL-1β and TNF-α protein in the liver of PQ-treated mice are inhibited by neohesperidin dihydrochalcone. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6324 mL | 8.1622 mL | 16.3244 mL | 32.6488 mL |
| 5mM | 0.3265 mL | 1.6324 mL | 3.2649 mL | 6.5298 mL |
| 10mM | 0.1632 mL | 0.8162 mL | 1.6324 mL | 3.2649 mL |
| 20mM | 0.0816 mL | 0.4081 mL | 0.8162 mL | 1.6324 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.