NEK6 inibitor 8 (ZINC-05007751)

This product is for research use only, not for human use. We do not sell to patients.

NEK6 inibitor 8 (ZINC-05007751)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$110To Be Confirmed
10mg$170To Be Confirmed
50mg$540To Be Confirmed
email: [email protected]        [email protected]

Cat #: V42133 CAS #: 591239-68-8 Purity ≥ 99%

Description: ZINC05007751 is a potent inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 μM. ZINC05007751 showed antiproliferation activity against a panel of human cancer/tumor cell lines and showed synergistic effects with cisplatin and paclitaxel in BRCA2-mutated ovarian cancer/tumor cell lines. ZINC05007751 has strong selectivity for NEK1 and NEK6, but has no obvious activity against NEK2, NEK7 and NEK9.

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Molecular Weight (MW)304.29948425293
Molecular FormulaC18H12N2O3
CAS No.591239-68-8
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage.  (2). This product is not stable in solution, please use freshly prepared working solution for optimal results.

SynonymsZINC05007751; ZINC-05007751; ZINC 05007751
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.2862 mL16.4312 mL32.8624 mL65.7247 mL
5mM0.6572 mL3.2862 mL6.5725 mL13.1449 mL
10mM0.3286 mL1.6431 mL3.2862 mL6.5725 mL
20mM0.1643 mL0.8216 mL1.6431 mL3.2862 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.