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ND-646

This product is for research use only, not for human use. We do not sell to patients.

ND-646
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$1800Check With Us
1g$2800Check With Us
5g$7085Check With Us
email: [email protected]        [email protected]

Cat #: V26327 CAS #: 1434639-57-2 Purity ≥ 99%

Description: ND-646 is-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo.

References: Svensson RU, et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 Oct;22(10):1108-1119.

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Molecular Weight (MW)568.64
Molecular FormulaC28H32N4O7S
CAS No.1434639-57-2
SMILES CodeCC(C)(N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC=CO5)S3)=O)C4=O)C(N)=O
SynonymsND-646; ND 646; ND646
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7586 mL8.7929 mL17.5858 mL35.1716 mL
5mM0.3517 mL1.7586 mL3.5172 mL7.0343 mL
10mM0.1759 mL0.8793 mL1.7586 mL3.5172 mL
20mM0.0879 mL0.4396 mL0.8793 mL1.7586 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.