This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 100mg | $3570 | To Be Confirmed |
| 200mg | $5355 | To Be Confirmed |
| 500mg | $9035 | To Be Confirmed |
: Cat #: V2697 CAS #: 1508256-20-9 Purity ≥ 98%
Description: Nazartinib S-enantiomer is the S-isomer of Nazartinib which is a novel, covalent/irreversible, mutant-selective EGFR inhibitor with Ki and Kinact of 31 nM and 0.222 min−1 on EGFR(L858R/790M) mutant, respectively.
References: Gerald Lelais, et al. Compounds and compositions for modulating egfr activity. WO 2013184757A1.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 495.02 |
|---|---|
| Molecular Formula | C₂₆H₃₁ClN₆O₂ |
| CAS No. | 1508256-20-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 99 mg/mL (200mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 99 mg/mL (200mM) | |
| Solubility In Vivo | O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)=C4 |
| Synonyms | EGF816 S-enantiomer; EGF-816 S-enantiomer; EGF 816 S-enantiomer; NVS-816 S-enantiomer; NVS 816; NVS816; Nazartinib S-enantiomer |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0201 mL | 10.1006 mL | 20.2012 mL | 40.4024 mL |
| 5mM | 0.4040 mL | 2.0201 mL | 4.0402 mL | 8.0805 mL |
| 10mM | 0.2020 mL | 1.0101 mL | 2.0201 mL | 4.0402 mL |
| 20mM | 0.1010 mL | 0.5050 mL | 1.0101 mL | 2.0201 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.