Naspm trihydrochloride (1-Naphthylacetyl spermine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1380 | To Be Confirmed |
| 500mg | $2150 | To Be Confirmed |
| 1g | $3225 | To Be Confirmed |
: Cat #: V5146 CAS #: 1049731-36-3 Purity ≥ 98%
Description: Naspm 3HCl (1-Naphthylacetyl spermine trihydrochloride), the trihydrochloride salt of Naspm, is a synthetic analog of Joro spider toxin and a calcium permeable AMPA (CP-AMPA) receptors antagonist.
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| Molecular Weight (MW) | 479.91 |
|---|---|
| Molecular Formula | C₂₂H₃₇Cl₃N₄O |
| CAS No. | 1049731-36-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0837 mL | 10.4186 mL | 20.8372 mL | 41.6745 mL |
| 5mM | 0.4167 mL | 2.0837 mL | 4.1674 mL | 8.3349 mL |
| 10mM | 0.2084 mL | 1.0419 mL | 2.0837 mL | 4.1674 mL |
| 20mM | 0.1042 mL | 0.5209 mL | 1.0419 mL | 2.0837 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.